(HealthDay)—For women undergoing in vitro fertilization (IVF), use of cryopreserved versus fresh donor oocytes is associated with marginally, but statistically significant, lower odds of a good perinatal outcome, according to a study published online Feb. 6 in Obstetrics & Gynecology.
Jennifer L. Eaton, M.D., from the Duke University Medical Center in Durham, North Carolina, and colleagues conducted a retrospective cohort study of women undergoing donor oocyte IVF from 2012 to 2015 to compare the odds of a good perinatal outcome between cryopreserved and fresh donor oocytes. Data were included for 36,925 cycles: 22.7 and 77.3 percent used cryopreserved and fresh oocytes, respectively.
The researchers found that before and after covariate adjustment, the odds of a good perinatal outcome were marginally but significantly lower with cryopreserved versus fresh oocytes (22.0 versus 24.1 percent; unadjusted odds ratio, 0.90; adjusted odds ratio, 0.88). Cryopreserved oocytes were associated with lower rates of live birth (39.6 versus 47.7 percent; odds ratio, 0.75), multiple birth (22.3 versus 31.2 percent; odds ratio, 0.63), and prematurity (27.6 versus 30.6 percent; odds ratio, 0.86) compared with fresh oocytes.
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